Dorothy Chyung's Internship Experience
My project focused on a potential target gene for artemisinin-based drugs. Artemisinin was first used in ancient Chinese medicine. Currently, artemisinin-combination therapy is one of the major antimalarial drugs. Although it is being widely used, its exact mechanism is unknown. Further information regarding its target would be helpful to create new derivatives and to combat resistance.
This summer I worked on making vector constructs for P. berghei and P. falciparum, modifying one potential target gene. The constructs included a gene-knockout to test the necessity of this gene, a gene replacement to compare drug potency, and a fluorescent tag to locate its function. Lab work requires patience and dedication, but it is fun learning new techniques and socializing with fellow researchers. Doing research in the summer is far more intense and productive than doing it in the school year.
It is exciting to be so integrated in scientific innovation and for your work to be meaningful in the real world. Working in Thailand was a blast. I learned a lot about Thai culture (they love their king and walk more slowly), learned about Thai lab culture (they wear lab coats and keep detailed information about who uses equipment), had adventures (riding elephants and petting tigers), and ate a lot of amazing food. The most important thing in choosing a lab is to have a genuine interest in the lab’s work. At the same time, location should also be taken into consideration when traveling for a few months. Doing this program is a unique way to experience another country, and a great opportunity for a fun (but productive) summer.
